Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI2C7), TrueMAB
ABCB1 단백질을 표적하는 Mouse IgG1 단일클론 항체로 Western blot과 IHC에 사용 가능. 인간 시료 반응성. 무보존제, 동결건조 형태로 제공되며 재구성 후 1 mg/mL 농도. 다약제 내성 연구 및 약물 수송 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The ABCB1 gene encodes a membrane-associated protein belonging to the ATP-binding cassette (ABC) transporter superfamily.
ABCB1 functions as an ATP-dependent drug efflux pump with broad substrate specificity, contributing to multidrug resistance and reduced intracellular drug accumulation.
It also acts as a transporter in the blood-brain barrier, playing a key role in xenobiotic compound transport.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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