Thermo Fisher Scientific MBNL1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa, Jurkat
• Predicted reactivity: Mouse (98%), Rat (99%), Chicken (97%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

EGFR (Epidermal Growth Factor Receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of receptor tyrosine kinases, including ERbB2, ERbB3, and ERbB4. Ligand binding (e.g., EGF, TGF-α) induces receptor dimerization and autophosphorylation, activating downstream signaling pathways such as Ras-ERK, PI3K-Akt, Jak-STAT, and PKC. These cascades regulate cell growth and proliferation. EGFR phosphorylation at Y1086 promotes GRB2 binding and MAPK pathway activation. Receptor activation leads to endocytosis and degradation or recycling. EGFR mutations and overexpression are linked to various cancers, including lung, head and neck, brain, and breast tumors, and are often associated with poor prognosis.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.