Thermo Fisher Scientific MBNL1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human MBNL1 protein. Validated for WB and ICC/IF applications. High specificity and purity via antigen affinity chromatography. Supplied in liquid form with glycerol for stability. Suitable for research use only.
- 카탈로그번호
- PA529825
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MBNL1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–259 of Human Muscleblind-like 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547299 |
Product Specific Information
- Recommended positive controls: A549, HeLa, Jurkat
- Predicted reactivity: Mouse (98%), Rat (99%), Chicken (97%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
EGFR (Epidermal Growth Factor Receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of receptor tyrosine kinases, including ERbB2, ERbB3, and ERbB4. Ligand binding (e.g., EGF, TGF-α) induces receptor dimerization and autophosphorylation, activating downstream signaling pathways such as Ras-ERK, PI3K-Akt, Jak-STAT, and PKC. These cascades regulate cell growth and proliferation. EGFR phosphorylation at Y1086 promotes GRB2 binding and MAPK pathway activation. Receptor activation leads to endocytosis and degradation or recycling. EGFR mutations and overexpression are linked to various cancers, including lung, head and neck, brain, and breast tumors, and are often associated with poor prognosis.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.