Thermo Fisher Scientific CD43 Monoclonal Antibody (MEM-59), Alexa Fluor 700

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 4 µL / 1×10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Biotin
• FITC
• PE
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes a neuraminidase-sensitive extracellular epitope on CD43 (Leukosialin), a 95–135 kDa type I transmembrane glycoprotein (mucin-type) involved in lymphocyte activation.
CD43 is expressed by platelets and highly on all leukocytes but is negative on resting B lymphocytes and erythrocytes.
Recommended dilution: 100 µL of whole blood or 1×10^6 cells in suspension.

Target Information

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with a high negative charge, expressed on most hematopoietic cells. It contributes to a repulsive barrier that interferes with cellular adhesion but can promote leukocyte aggregation.
Through interaction with actin-binding proteins (ezrin and moesin), CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte traffic.
CD43 signaling modulates LFA-1 adhesiveness and can induce tumor suppressor p53; however, in p53 and ARF deficiencies, it may promote tumor proliferation.
Dysfunction of CD43 is associated with Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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