Thermo Fisher Scientific DR3 Monoclonal Antibody (59204)
DR3 단백질을 인식하는 Thermo Fisher Scientific의 mouse monoclonal antibody. Western blot에 최적화되어 있으며, 인간 및 생쥐 시료에 반응. Protein A/G로 정제된 동결건조 형태로 제공되며, PBS + 5% 트레할로스 완충액에 재구성 가능.
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Applications
- Western Blot (WB): Tested at 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 59204 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human DR3 isoform 1 (Gln25–Phe201) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606220 |
Product Specific Information
This antibody shows 100% cross-reactivity with recombinant mouse DR3/TNFRSF25 and no cross-reactivity with recombinant human 4-1BB, CD27, CD30, CD40, DR6, BAFF R, Fas, GITR, LTR beta, NGF R, OPG, OX40, RANK, TAJ, TNF RI, TNF RII, or HVEM.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
DR3/TNFRSF25 is a member of the TNF-receptor superfamily. It is preferentially expressed in lymphocyte-rich tissues and may regulate lymphocyte homeostasis. DR3 stimulates NF-kappa B activity and influences cell apoptosis through death domain-containing adaptor proteins. Mouse knockout studies suggest its role in removing self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants exist, many encoding secreted isoforms. In activated T cells, alternative splicing shifts toward full-length, membrane-bound forms, contributing to lymphocyte proliferation control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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