Thermo Fisher Scientific CD8A (Cytotoxic- and Suppressor T-Cell Marker) Monoclonal Antibody (C8/468), CF 488
CD8A 단백질을 표적하는 단클론 항체로, 세포독성 및 억제성 T세포 마커 검출에 사용됩니다. 인간 시료에 반응하며 CF® 488 형광으로 결합되어 ICC/IF 및 유세포분석에 적합합니다. 단백질 A/G로 정제된 고품질 항체로 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CD8A (Cytotoxic- and Suppressor T-Cell Marker) Monoclonal Antibody (C8/468), CF 488
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 5 µL/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C8/468 |
| Immunogen | Recombinant human CD8 protein |
| Conjugate | CF® 488 |
| Excitation / Emission Max | 488 / 515 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a key role in T cell signal transduction, differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β) and functions as a co-receptor with TCR for MHC-I molecules. CD8α is essential for MHC-I binding and is also found as homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells. Engagement of MHC-I/peptide complexes triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naïve CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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