Thermo Fisher Scientific CD8A (Cytotoxic-andSuppressor T-Cell Marker) Monoclonal Antibody (C8/468)

Applications and Tested Dilutions

Product Specifications

Additional Formats

• CF 488 conjugate available
• Custom conjugation available upon request

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a critical role in signal transduction, T cell differentiation, and activation. CD8 is primarily expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. In contrast, CD4 serves as a co-receptor for MHC class II molecules.

CD8α is essential for MHC-I binding and is also expressed as homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells. Engagement of MHC-I/peptide complexes on antigen-presenting cells (APCs) recruits Lck kinase, triggering lymphokine production, motility, and activation of cytotoxic T lymphocytes (CTLs). Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.