Thermo Fisher Scientific STAT5A Monoclonal Antibody (OTI8H1), TrueMAB

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, forming homo- or heterodimers that translocate to the nucleus and act as transcription activators.
STAT5 alpha mediates responses to ligands such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones.
Activation of STAT5 alpha is associated with TEL/JAK2 gene fusion in myeloma and lymphoma, contributing to tumorigenesis.
In mice, STAT5 alpha induces BCL2L1/BCL-X(L) expression, suggesting an anti-apoptotic role. STAT5 alpha and STAT5 beta share 96% sequence similarity and are co-expressed in most tissues, with differential mRNA accumulation in muscle and mammary tissue.
STAT5 alpha plays key roles in reproduction, lactation, immune regulation, and somatic growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.