Thermo Fisher Scientific ITM2B Monoclonal Antibody (OTI1C11), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides forming the characteristic plaques of Alzheimer’s disease.
The ITM2B gene encodes a transmembrane protein processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide that inhibits beta-amyloid deposition.
Mutations extending the C-terminal end of the encoded protein are associated with familial British dementia and familial Danish dementia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.