Thermo Fisher Scientific STAT5A Monoclonal Antibody (OTI10H1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, forming homo- or heterodimers that translocate to the nucleus to act as transcription activators. STAT5 alpha mediates responses to ligands such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones.

Activation of STAT5 alpha in myeloma and lymphoma associated with TEL/JAK2 gene fusion is independent of cell stimulus and is essential for tumorigenesis. In mouse, STAT5 alpha induces expression of BCL2L1/BCL-X(L), suggesting an anti-apoptotic role. STAT5 alpha and STAT5 beta share 96% sequence similarity and are co-expressed in most tissues, with differential mRNA accumulation observed in muscle and mammary tissues. STAT5 alpha plays critical roles in reproduction, lactation, immune function, and somatic growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.