Thermo Fisher Scientific RHOH Monoclonal Antibody (3D3)

Thermo Fisher Scientific RHOH Monoclonal Antibody (3D3)

Applications

• ELISA (ELISA)
  Tested Dilution: 1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MLSSIKCVLV GDSAVGKTSL LVRFTSETFP EAYKPTVYEN TGVDVFMDGI QISLGLWDTA GNDAFRSIRP LSYQQADVVL MCYSVANHNS FLNLKNKWIG EIRSNLPCTP VLVVVTQTDQ REMGPHRASC VNAMEGKKLA QDVRAKGYLE CSALSNRGVQ QVFECAVRTA VNQARRRNRR RLFSINECKI F

Target Information

The Rho subfamily of small GTP-binding proteins mediates many fundamental cellular functions. Members such as Rho, Rac, and CDC42 regulate actin reorganization and affect cellular responses including adhesion, cytokinesis, and motility.

RhoH (also known as TTF, Translocation Three Four) is distinct from most small G proteins. While most are ubiquitously expressed, RhoH is expressed only in hemopoietic cells and tissues. Translocations and frequent RhoH mutations have been detected in primary lymphoma cells, and expression has been observed in activated neutrophils.

RhoH is GTPase-deficient, remaining in a GTP-bound activated state. It may play a role in T cell differentiation and cytoskeleton organization. The RhoH/TTF (ARHH) gene maps to chromosome 4p13 and encodes a 191-amino acid polypeptide.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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