Thermo Fisher Scientific PHOX2A Monoclonal Antibody (4F6)
PHOX2A 단백질을 인식하는 Mouse 모노클론 항체로, Human 및 Rat 시료에 반응합니다. Western blot, ICC/IF, ELISA 등에 사용 가능하며, PBS 기반 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4F6 |
| Immunogen | PHOX2A (NP_005160, 1–90 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP ALGSSNCALG ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ
Target Information
PHOX2A and PHOX2B are paired-homeodomain transcription factors that determine the noradrenergic phenotype during embryogenesis.
PHOX2 proteins regulate endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation.
Human PHOX2B contains one DNA binding homeobox domain and is required for differentiation of all central and nonperipheral noradrenergic centers in the brain, whereas PHOX2A controls differentiation of the main noradrenergic center.
Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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