Thermo Fisher Scientific ARHGDIG Monoclonal Antibody (1D11)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

3 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

1D11

Immunogen

ARHGDIG (AAH47699, 1 a.a. approximately 225 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ARHGDIG,uniProtId:Q99819-1,ncbiNodeId:9606,antigenRange:1-225,antigenLength:225,antigenImageFileName:H00000398-M01_ARHGDIG_Q99819-1_House_mouse.svg,antigenImageFileNamePDP:H00000398-M01_ARHGDIG_Q99819-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MLGLDACELG AQLLELLRLA LCARVLLADK EGGPPAVDEV LDEAVPEYRA PGRKSLLEIR QLDPDDRSLA KYKRVLLGPL PPAVDPSLPN VQVTRLTLLS EQAPGPVVMD LTGDLAVLKD QVFVLKEGVD YRVKISFKVH REIVSGLKCL HHTYRRGLRV DKTVYMVGSY GPSAQEYEFV TPVEEAPRGA LVRGPYLVVS LFTDDDRTHH LSWEWGLCIC QDWKD

Target Information

The Ras superfamily of small GTP-binding proteins are critical mediators of diverse cell signaling pathways, including those leading to proliferation, cytoskeletal organization and secretion. The counter-conversion of the active GTPbound form of these proteins to their inactive GDP-bound form is influenced by two types of regulatory proteins: those that alter the intrinsic GTPase activity of the GTP-binding proteins and those that alter the rate of GDP/GTP exchange. Guanine nucleotide-releasing factors (GRFs) increase the GDP dissociation rate, while GDP-dissociation inhibitors (GDIs) decrease the dissociation rate. The Rho GDI subfamily is composed of Rho GDIalpha, Ly-GDI (also known as Rho GDIbeta and previously known as GDI/D4) and Rho GDIgamma. The Rho GDI proteins interact with and have varying affinities for several Ras-like GTP binding proteins, including Rho A, Rho B, Rac and Cdc42. Ly-GDI is expressed only in hematopoietic cells, predominantly in B and T lymphocyte cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.