Thermo Fisher Scientific Human WISP-3 Recombinant Protein, PeproTech

Applications

Immunoprecipitation (IP)

• Tested dilution: Not specified
• Publications: View 1 publication

Functional Assay

• Assay-dependent
• Publications: View publication

In vitro Assay (IV)

• Tested dilution: Not specified
• Publications: View 2 publications

Miscellaneous PubMed (Misc)

• Tested dilution: Not specified
• Publications: View 1 publication

Product Specifications

Product Specific Information

• Catalog No. 120-20-1MG: Provided as 4 × 250 µg (120-20-250UG)
• Catalog No. 120-20-500UG: Provided as 2 × 250 µg (120-20-250UG)
• Recombinant Human WISP-3 is a 36.8 kDa protein containing 331 amino acids.
• Composed of four structural domains:
  1. IGF binding protein (IGFBP) domain
  2. von Willebrand Factor C (VWFC) domain
  3. Thrombospondin type-1 repeat (TSP type-1) domain
  4. C-terminal cysteine knot-like (CTCK) domain
• Shipped at ambient temperature. Refer to lot-specific Certificate of Analysis for storage, handling, and reconstitution details.

Target Information

WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, belonging to the connective tissue growth factor (CTGF) family.
WNT1 proteins are cysteine-rich, glycosylated signaling molecules involved in diverse developmental processes.
CTGF family members share four conserved cysteine-rich domains:

• Insulin-like growth factor-binding domain
• von Willebrand factor type C module
• Thrombospondin domain
• C-terminal cystine knot-like domain

WISP3 is overexpressed in colon tumors and may act downstream of WNT1 in malignant transformation.
Mutations in WISP3 are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating its essential role in skeletal growth and cartilage homeostasis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.