Thermo Fisher Scientific ATM Polyclonal Antibody, DyLight 650
ATM 단백질을 인식하는 DyLight 650 결합 토끼 폴리클로날 항체. Western blot, IHC, ICC, Flow cytometry, ELISA에 사용 가능. 항원 친화 크로마토그래피로 정제. 4°C 암소 보관, 형광 파장 651/673 nm.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:100 | |
| Flow Cytometry (Flow) | Assay-dependent | |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Marsupial, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A fragment of human ATM protein expressed in E. coli. The fragment relates to the C-terminal region (within the last third of the protein sequence). |
| Conjugate | DyLight™ 650 |
| Excitation/Emission Max | 651/673 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 50 mM sodium borate |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152632 |
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immune deficiency, and increased risk of lymphoid cancer. The ATM gene encodes a protein in the phosphoinositide 3-kinase (PI3K) superfamily, functioning as a protein kinase with downstream targets such as P53, Mdm2, BRCA1, and SMC1.
ATM plays a critical role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. The C-terminal region of ATM shares homology with catalytic domains of PI3 kinases. ATM becomes autophosphorylated and activated upon exposure to ionizing radiation, triggering kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair. ATM is also linked to apoptosis regulation through interactions with Nbs1 and Chk2 in the E2F1 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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