Thermo Fisher Scientific STMN4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human STMN4 (NP_1104222)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.3 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806321

Product Specific Information

Immunogen sequence: MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEGWCG RQCRRKDESQ RKDSADWRER RAQADTVDLN WCVISDMEVI ELNKCTSGQS FEVILKPPSF DGVPEFNASL PRRRDPSLEE IQKKLEAAEE RRKYQEAELL KHLAEKREHE REVIQKAIEE NNNFIKMAKE KLAQKMESNK ENREAHLAAM LERLQEKDKH AEEVRKNKEL KEEASR; Positive Samples: Mouse spinal cord, Rat spinal cord; Cellular Location: Cell projection, Golgi apparatus, axon, growth cone

Target Information

RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.