Thermo Fisher Scientific MIP-3 beta Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• In sandwich ELISAs, less than 0.05% cross-reactivity with recombinant mouse MIP-3 beta, recombinant human GRO alpha, HCC-4, Eotaxin, mouse MIP-3 alpha, rat MIP-3 alpha, and human MIP-3 alpha is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).

Target Information

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC subfamily of chemokines. It is closely related to CCL21, sharing 32% amino acid sequence homology. Both are expressed mainly by stromal cells in T cell-rich zones of lymph nodes and are key mediators of homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs. They also contribute to T cell priming, activation, and lymphocyte recruitment to inflamed tissues. Both signal via the G protein-coupled receptor CCR7, expressed on T cells and mature dendritic cells. Although both ligands bind CCR7 with similar affinity, only CCL19 binding induces receptor desensitization and internalization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.