Thermo Fisher Scientific OCRL Polyclonal Antibody
Thermo Fisher Scientific의 OCRL Polyclonal Antibody는 인간 OCRL 단백질을 인식하는 토끼 유래 IgG 항체로, Western blot, IHC, ICC/IF에 적합합니다. 고순도 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용됩니다.
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- PA527844
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 591–897 of Human OCRL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545320 |
Product Specific Information
- Recommended positive controls: 293T, A431
- Predicted reactivity: Mouse (95%), Rat (96%), Rhesus Monkey (96%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, generating second messengers in response to extracellular signals.
OCRL1 is a type II 5-phosphatase mutated in the oculocerebrorenal syndrome of Lowe (OCRL), a rare X-linked disorder characterized by congenital cataracts, mental retardation, muscular hypotonia, and renal tubular dysfunction.
OCRL1 has a high affinity for phosphatidylinositol 4,5-bisphosphate as well as inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate as substrates.
OCRL1 is localized to the Golgi complex and is thought to be part of the trans-Golgi network (TGN), suggesting its role in protein sorting and trafficking within the cell.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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