Thermo Fisher Scientific MUTYH Polyclonal Antibody
Thermo Fisher Scientific의 MUTYH Polyclonal Antibody는 인간 및 생쥐 시료에 반응하며, Western blot과 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 액상 항체로, DNA 손상 복구 관련 연구에 활용됩니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MUTYH Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 257–546 of Human MUTYH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.16 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2545331 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, NIH-3T3
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MYH (mutY homolog (E. coli)) is a DNA glycosylase mismatch repair enzyme that cooperates with mutM (OGG1) to remove adenine residues mispaired with oxidized or normal guanines, correcting A/G and A/C mismatches.
DNA glycosylases initiate base excision repair by cleaving N-glycosyl bonds. MYH prevents mutations from oxidative DNA damage and exists in multiple N-terminal splice variants in mammalian cells.
Elevated MYH levels in A549 cells exposed to oxygen and infrared radiation improve cell survival. Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons, maintaining mitochondrial DNA integrity against reactive oxygen species throughout the mammalian lifespan.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일은 하단에 배치됩니다)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.