Thermo Fisher Scientific Phospho-Chk1 (Ser345) Recombinant Rabbit Monoclonal Antibody (HL122)
Phospho-Chk1 (Ser345) 특이적 토끼 단클론 항체로, 인간 CHK1 단백질의 인산화 상태 검출에 적합. Western blot에 최적화되어 있으며, 고순도 Protein A 정제 및 1 mg/mL 농도로 제공. 연구용으로 DNA 손상 반응 및 세포주기 조절 연구에 활용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-Chk1 (Ser345) Recombinant Rabbit Monoclonal Antibody (HL122)
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL122 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Chk1 (phospho Ser345) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911494 |
Product Specific Information
- Store as concentrated solution.
- Centrifuge briefly prior to opening vial.
- For short-term storage (1–2 weeks), store at 4°C.
- For long-term storage, aliquot and store at -20°C or below.
- Avoid multiple freeze-thaw cycles.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised.
CHK1 is a key mediator in the DNA damage-induced checkpoint network and functions to ensure genomic integrity upon genotoxic stress.
When the G2 or S checkpoint is abrogated by inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells remain arrested in the G1 phase.
Thus, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer therapy, making Chk1 an attractive therapeutic target, particularly in p53-deficient cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.