Thermo Fisher Scientific DDR2 Recombinant Rabbit Monoclonal Antibody (HL1107)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent
• Publications: References

Product Specifications

Product Specific Information

Store as concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.

Target Information

DDR2 is a member of a subclass of receptor tyrosine kinases (RTKs) and contains a distinct extracellular region with a factor VIII-like domain. DDR1 and DDR2 are potently inhibited by Gleevec. DDR2 is required for normal bone development and regulates osteoblast differentiation and chondrocyte maturation via MAP kinase signaling leading to activation of RUNX2. It also regulates extracellular matrix remodeling by up-regulating collagenases MMP1, MMP2, and MMP13, facilitating cell migration and tumor invasion. DDR2 promotes fibroblast migration and proliferation, contributing to cutaneous wound healing.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.