Thermo Fisher Scientific NOTCH2 Chimeric Recombinant Mouse Monoclonal Antibody (B6)
NOTCH2 단백질을 인식하는 Thermo Fisher의 키메라형 재조합 마우스 단클론 항체입니다. 인간 및 마우스 반응성이 있으며, ICC/IF, ELISA, 억제 분석에 사용 가능합니다. 단백질 A로 정제된 액상 제품으로 1 mg/mL 농도이며, 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| ELISA | Assay-dependent | - |
| Inhibition Assays (IA) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | B6 |
| Immunogen | NRR of mouse Notch 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074266 |
Product Specific Information
Specificity: An engineered ScFv fragment antibody that binds to both mouse mNRR2 and human hNRR2, but not NRR1.
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein.
NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.
NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity and cholestasis, along with cardiac, skeletal, and ophthalmologic manifestations, and occasionally renal and vascular involvement.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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