Thermo Fisher Scientific NOTCH2 Chimeric Recombinant Mouse Monoclonal Antibody (B6)

Applications

Product Specifications

Product Specific Information

Specificity: An engineered ScFv fragment antibody that binds to both mouse mNRR2 and human hNRR2, but not NRR1.

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein.
NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.
NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity and cholestasis, along with cardiac, skeletal, and ophthalmologic manifestations, and occasionally renal and vascular involvement.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.