Thermo Fisher Scientific NOTCH2 Chimeric Recombinant Rabbit Monoclonal Antibody (B6)
NOTCH2 단백질을 인식하는 재조합 토끼 단클론 항체로 인간 및 생쥐 시료에 반응합니다. ICC/IF, ELISA, 억제 분석 등 다양한 응용 가능. HEK293 세포에서 발현된 비결합형 항체이며 Protein A로 정제됨. 장기 보관 시 -20°C에서 보관 권장.
- 판매단위
- pk
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Thermo Fisher Scientific NOTCH2 Chimeric Recombinant Rabbit Monoclonal Antibody (B6)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | B6 |
| Immunogen | NRR of mouse Notch 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074267 |
Product Specific Information
Specificity: Engineered ScFv fragment antibody that binds to both mouse mNRR2 and human hNRR2, but not NRR1.
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved protein in the Notch signaling pathway. It is a type I transmembrane protein with an extracellular domain composed of multiple EGF-like repeats and an intracellular domain with diverse domain types.
NOTCH2 acts as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1, regulating cell-fate determination.
Mutations in NOTCH2 cause Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity, cholestasis, and associated cardiac, skeletal, and ophthalmologic abnormalities. Facial features and occasional renal or vascular involvement may also occur.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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