Thermo Fisher Scientific EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Recombinant Rabbit Monoclonal Antibody (GFR/2600R)
EGFRvIII 변이 단백질을 특이적으로 인식하는 재조합 토끼 단클론 항체. 인체 시료에 반응하며 IHC(P), IHC(PFA) 실험에 적합. 고순도의 Protein A/G 정제 항체로 4°C 보관. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | GFR/2600R |
| Immunogen | KLH conjugate of EGFRvIII-specific, 14-amino acid peptide from the predicted amino acid sequence at the fusion junction (LEEKKGNYVVTDHC) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3, -4 (HER-1, -2, -3, -4). It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-α (TGF-α), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin, and epiregulin. EGFR is overexpressed in tumors of the breast, brain, bladder, lung, gastric, head and neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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