Thermo Fisher Scientific CD19 Monoclonal Antibody (6OMP31), eBioscience
CD19 단백질을 인식하는 6OMP31 클론의 Rat 모노클로날 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF 등에 사용 가능하며, PBS buffer에 0.5 mg/mL 농도로 제공됩니다. B세포 발달 및 면역반응 연구에 적합합니다.
- 카탈로그번호
- 14-0194-xx (4개 옵션)
- 판매단위
- pk
카탈로그
4개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD19 Monoclonal Antibody (6OMP31), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | 1 publication |
| Immunohistochemistry (IHC) | - | 8 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–5 µg/mL | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 0.5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
| Flow Cytometry (Flow) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6OMP31 |
| Immunogen | E. coli fragment (aa 314–556) of the cytoplasmic domain of CD19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2864834 |
Additional Formats:
Product Specific Information
Description:
The 6OMP31 monoclonal antibody reacts with human, mouse, and rat CD19. CD19 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and is expressed by B cells during all stages of development except on terminally differentiated plasma cells. It also appears on follicular dendritic cells.
CD19 acts as a B cell co-receptor and forms a complex with CD21, CD81, Leu13, and MHC class II that associates with the B cell receptor (BCR). It plays a key role in B cell development, activation, and proliferation. CD19 deficiency leads to impaired humoral immune response, while mutations are linked to immunodeficiency syndromes. CD19 is expressed on most B cell tumors, including acute lymphoblastic leukemias and B cell lymphomas. Therapeutic applications targeting CD19 are being explored for lymphoma, leukemia, and autoimmune disorders.
Applications Reported:
This antibody is reported for use in:
- Western blotting
- Immunohistochemistry (frozen and paraffin-embedded sections)
Applications Tested:
- IHC (paraffin): ≤ 0.5 µg/mL (low or high pH antigen retrieval)
- IHC (frozen): ≤ 0.5 µg/mL
- Optimal dilution should be determined experimentally.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD19 is a member of the immunoglobulin superfamily with two Ig-like domains. It is expressed on 100% of peripheral B cells and may also appear on certain myeloid leukemia cells. CD19 functions as a signal-amplifying co-receptor for the B cell receptor (BCR), regulating B cell proliferation and differentiation. Mutations in CD19 lead to hypogammaglobulinemia, while overexpression causes B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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