Thermo Fisher Scientific ITGB1 Monoclonal Antibody (3B6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-17103 targets ITGB1 in FACS, IHC, indirect ELISA, and WB applications, showing reactivity with Human and Non-human primate samples.
The immunogen is a purified recombinant fragment of human ITGB1 expressed in E. coli.
MA5-17103 detects ITGB1 with a predicted molecular weight of approximately 88.4 kDa.

Target Information

ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein widely expressed in various cells including all leukocytes.
It forms non-covalently linked heterodimers with at least six different alpha chains (α1–α6, CDa–f), determining the binding properties of beta1 (VLA) integrins.
ITGB1 acts as a cell adhesion molecule on platelets and as a component of protein complexes binding extracellular matrix proteins.
Decreased ITGB1 expression correlates with multidrug resistance in tumor cells under anti-tumor drug exposure.
ITGB1 is up-regulated in leukocytes during emigration and extravascular migration, regulating immune cell trafficking.
It also plays roles in tissue damage and inflammatory bowel disease pathophysiology.
Fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle via ITGB1-dependent mechanisms.
More than eight beta subunits and numerous splice variants have been identified in mammals.
Two major forms, beta1A and beta1D, differ by 13 amino acids; beta1A is present in all tissues except cardiac and skeletal muscle, which express beta1D.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.