Thermo Fisher Scientific TRPV6 Polyclonal Antibody, Biotin
TRPV6 단백질을 인식하는 Biotin 결합 폴리클로날 항체로, Western blot, ELISA, Immunoprecipitation에 사용 가능. 인간, 마우스, 랫트 반응성. 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용.
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Thermo Fisher Scientific TRPV6 Polyclonal Antibody, Biotin
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from amino acids 700–732 of TRPV6 protein, covalently modified and coupled to a carrier protein using a heterobifunctional cross linker. |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, containing 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Calcium-permeable channels such as TRPV6 are involved in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA). TRPV6 functions as a calcium-selective cation channel and participates in calcium uptake in various tissues, including intestinal calcium reabsorption.
The channel is activated by low internal calcium levels and shows inward rectification. Inactivation occurs via rapid Ca(2+)-dependent and slower Ca(2+)-calmodulin-dependent mechanisms, potentially regulated by phosphorylation. TRPV6 is slowly inhibited by Mg(2+) in a voltage-independent manner in vitro. It forms heteromeric assemblies with TRPV5, modifying channel properties and exhibiting voltage-dependent gating. TRPV6 interacts with TRPV5, S100A10, ANAX2-S100A10 heterotetramer, BSPRY, and calmodulin; the interaction with S100A10 is required for plasma membrane trafficking.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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