Thermo Fisher Scientific TRPV6 Polyclonal Antibody
TRPV6 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ELISA, IP에 사용 가능. 인체, 마우스, 랫트 반응성. 합성 펩타이드 면역원 사용, Affinity chromatography로 정제. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from the region within amino acids 700–732 of TRPV6 protein. The peptide was covalently modified for antigenicity and coupled to a carrier protein via heterobifunctional cross linker. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Calcium-permeable channels such as TRPV6 are involved in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 functions as a calcium-selective cation channel, likely participating in Ca²⁺ uptake and reabsorption in various tissues including the intestine. The channel is activated by low internal calcium levels and exhibits inward rectification.
Inactivation mechanisms include rapid Ca²⁺-dependent and slower Ca²⁺-calmodulin-dependent processes, potentially regulated by phosphorylation. In vitro, TRPV6 is slowly inhibited by Mg²⁺ in a voltage-independent manner. Heteromeric assembly with TRPV5 modifies channel properties, and TRPV5–TRPV6 heteromultimers show voltage-dependent gating.
TRPV6 interacts with TRPV5, S100A10, ANAX2–S100A10 heterotetramer, BSPRY, and calmodulin. The interaction with S100A10 is essential for trafficking to the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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