Thermo Fisher Scientific TSC1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total TSC1.

Target Information

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes.
The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), a conserved serine/threonine kinase regulating cell growth and cycle via nutrient and growth factor signals.

TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high.
Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 complex decreases Rheb’s ability to stimulate TOR activity.
Overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and inhibition of cell growth.
A shorter 40 kDa isoform of TSC1 has been shown to exist, but its function remains unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.