Thermo Fisher Scientific TRPC4 Polyclonal Antibody
TRPC4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB 및 ICC/IF에 적합하며 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TRPC4 (Accession Q9UBN4), corresponding to amino acid residues V936–L977 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900712 |
Product Specific Information
Antibody detects endogenous levels of total TRPC4.
Target Information
TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels. It forms a non-selective calcium-permeable cation channel activated by Gq-coupled receptors and tyrosine kinases. TRPC4 plays roles in endothelial permeability, vasodilation, neurotransmitter release, and cell proliferation. SNPs in TRPC4 may be associated with generalized epilepsy with photosensitivity. Multiple alternatively spliced isoforms have been observed.
The TRPC subfamily (TRPC1–7) is closely related to the founding Drosophila TRP channel. Diseases associated with TRPC4 include photosensitive epilepsy. CaV3.3 encodes a low voltage-activated, T-type calcium channel involved in neuronal calcium signaling. Voltage-gated calcium channels (CaV) mediate calcium influx in excitable cells and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression. CACNA1I mutations are linked to childhood absence epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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