Thermo Fisher Scientific Pepsinogen I Monoclonal Antibody (8003 (99/12))
인간 Pepsinogen I를 인식하는 Mouse IgG1 단클론 항체로, IHC, ELISA, RIA에 사용 가능. 고친화도(4×10¹⁰ l/mol)로 정확한 단백질 검출에 적합. Protein A 정제, PBS 완충액에 0.1% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| ELISA | Assay-dependent |
| Radioimmune Assays (RIA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8003 (99/12) |
| Immunogen | Purified human pepsinogen I |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | <0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_935066 |
Product Specific Information
- MA1-83390 has an affinity of 4 × 10¹⁰ l/mol for human Pepsinogen I.
- Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for staining of paraffin sections.
- Mouse anti-human Pepsinogen I antibody, clone 8003, recognizes human Pepsinogen I, a zymogen secreted by chief cells in the stomach.
Target Information
PGA5 (Pepsinogen 5, group I / Pepsinogen A)
Pepsinogens are inactive precursors of pepsin, the major acid protease in the stomach. Pepsin is produced by removal of a 41-amino acid segment from the N-terminus of pepsinogen.
It is synthesized in the stomach lining, activated by hydrochloric acid, and functions optimally at pH 1–3. Pepsin cleaves peptide bonds involving aromatic amino acids, showing broad substrate specificity.
PGA5 belongs to the pepsin family (subfamily A1) and is the predominant endopeptidase in gastric juice. It is inhibited by ovUS-1, a uterine serpin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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