Thermo Fisher Scientific TWEAK Monoclonal Antibody (CARL-1)
인간 TWEAK(CD255)을 인식하는 mouse monoclonal antibody. IHC 및 Flow Cytometry에 사용 가능. Protein A로 정제된 액상 항체로, 1 mg/mL 농도. 4°C 보관, 동결 금지. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Flow Cytometry (Flow) | 1–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CARL-1 |
| Immunogen | Human CD255-transfected 2PK-3 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 8.0 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745565 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD255 (TWEAK), a type II transmembrane protein of the TNF superfamily that can weakly induce apoptosis in many cell types.
Target Information
TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF). It is a cell surface-associated type II transmembrane protein, though a smaller active form can be generated by cleavage near the membrane. TWEAK exhibits multiple biological activities, including:
- Stimulation of cell growth and angiogenesis
- Induction of inflammatory cytokines
- Induction of apoptosis
TWEAK likely signals via TweakR/Fn14, similar to other TNFSF members that bind receptors lacking death domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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