Thermo Fisher Scientific TWEAK Monoclonal Antibody (CARL-1)
인간 TWEAK 단백질을 인식하는 CARL-1 단클론 항체로, IHC, Flow Cytometry, 기능적 분석에 사용 가능. 비결합(Unconjugated) 형식이며 Protein A로 정제됨. 4°C 보관, 방부제 무첨가. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (IHC) | Assay-dependent | |
| Flow Cytometry (Flow) | 1–4 µg/mL | |
| Functional Assay | Assay-dependent | Functional Application: Neutralization |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CARL-1 |
| Immunogen | Human CD255-transfected 2PK-3 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 8.0 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745563 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD255/TWEAK, a type II transmembrane protein of the TNF superfamily that can weakly induce apoptosis in many cell types.
Functional Application: Neutralization.
Target Information
TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF). It is a type II transmembrane protein, with a smaller biologically active form generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including:
- Stimulation of cell growth and angiogenesis
- Induction of inflammatory cytokines
- Induction of apoptosis
TWEAK signals via TweakR/Fn14, similar to other TNFSF members that bind receptors lacking death domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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