Thermo Fisher Scientific CARMIL2 Polyclonal Antibody
CARMIL2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. 면역침전(IP)에 사용 가능하며, RLTPR/CARMIL2 단백질의 1125–1175 아미노산 영역을 항원으로 제작되었습니다. 연구용으로만 사용됩니다.
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Applications
Immunoprecipitation (IP)
- Tested Dilution: 15–20 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 1125 and 1175 of human Leucine-rich repeat-containing protein 16C (RLTPR/CARMIL2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Target Information
RLTPR/CARMIL2 (RGD motif, leucine-rich repeats, tropomodulin domain and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein that binds CAPZA2 (capping protein muscle actin Z-line alpha 2) with high affinity and decreases CAPZA2’s affinity for actin barbed ends.
RLTPR/CARMIL2 increases actin filament elongation rate in the presence of CAPZA2 but does not nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation.
It plays a crucial role in T cell costimulation via CD28, independent of its actin-uncapping function. Lack of functional RLTPR/CARMIL2 impedes Th1 and Th17 differentiation in CD4+ T cells, leading to combined immunodeficiency. Expression is also detected in B cells but seems not involved in BCR-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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