Thermo Fisher Scientific CARMIL2 Polyclonal Antibody

Applications

Immunoprecipitation (IP)

• Tested Dilution: 15–20 µL/mg of lysate

Product Specifications

Target Information

RLTPR/CARMIL2 (RGD motif, leucine-rich repeats, tropomodulin domain and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein that binds CAPZA2 (capping protein muscle actin Z-line alpha 2) with high affinity and decreases CAPZA2’s affinity for actin barbed ends.
RLTPR/CARMIL2 increases actin filament elongation rate in the presence of CAPZA2 but does not nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation.
It plays a crucial role in T cell costimulation via CD28, independent of its actin-uncapping function. Lack of functional RLTPR/CARMIL2 impedes Th1 and Th17 differentiation in CD4+ T cells, leading to combined immunodeficiency. Expression is also detected in B cells but seems not involved in BCR-mediated signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.