Thermo Fisher Scientific CARMIL2 Polyclonal Antibody
CARMIL2 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 시료에 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, IP 실험에 적합합니다. RLTPR/CARMIL2 단백질 연구 및 T세포 공동자극 관련 연구에 활용 가능합니다.
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Applications
Immunoprecipitation (IP)
- Tested Dilution: 15–20 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 1125 and 1175 of human Leucine-rich repeat-containing protein 16C (RLTPR). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/tris citrate, pH 7.0–8.0 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
RLTPR/CARMIL2 (RGD motif, leucine-rich repeats, tropomodulin domain, and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein that binds CAPZA2 (capping protein muscle actin Z-line alpha 2) with high affinity and decreases CAPZA2 affinity for actin barbed ends.
RLTPR/CARMIL2 enhances actin filament elongation in the presence of CAPZA2 but does not nucleate filaments. This interaction is essential for lamellipodial protrusion and cell translocation.
It is crucial for T cell costimulation via CD28, independent of its actin-uncapping function. Deficiency in RLTPR/CARMIL2 impairs Th1 and Th17 differentiation in CD4+ T cells, leading to combined immunodeficiency. Expression is also detected in B cells but not involved in BCR-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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