Thermo Fisher Scientific CARMIL2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:10,000–1:25,000

Immunoprecipitation (IP)

• Tested Dilution: 50–100 µL/mg of lysate

Product Specifications

Target Information

RLTPR/CARMIL2 (RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein that binds CAPZA2 (capping protein muscle actin Z-line alpha 2) with high affinity and decreases CAPZA2 affinity for actin barbed ends. RLTPR/CARMIL2 enhances actin filament elongation from seeds in the presence of CAPZA2, but does not nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation. RLTPR/CARMIL2 is crucial for T cell costimulation via CD28, independent of its actin-uncapping function. Deficiency of RLTPR/CARMIL2 impairs differentiation toward Th1 and Th17 fates in human and murine CD4+ T cells, leading to combined immunodeficiency. Expression is also detected in B cells but appears unrelated to BCR-mediated signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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