Thermo Fisher Scientific CARMIL2 Polyclonal Antibody
Rabbit polyclonal antibody against human CARMIL2 (RLTPR) for WB and IP applications. Targets region 1385–1435 of Leucine-rich repeat-containing protein 16C. Supplied as unconjugated liquid form, 1 mg/mL concentration. Stored at 4°C and shipped on wet ice.
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Thermo Fisher Scientific CARMIL2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:10,000–1:25,000 |
| Immunoprecipitation (IP) | 50–100 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 1385 and 1435 of human Leucine-rich repeat-containing protein 16C (RLTPR, UniProt ID: Q6F5E8-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Target Information
RLTPR/CARMIL2 (RGD motif, leucine-rich repeats, tropomodulin domain, and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein that binds CAPZA2 (capping protein muscle actin Z-line alpha 2) with high affinity and decreases CAPZA2 affinity for actin barbed ends. RLTPR/CARMIL2 increases the rate of actin filament elongation from seeds in the presence of CAPZA2 but does not nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation. RLTPR/CARMIL2 is crucial for T cell costimulation via CD28, independent of its actin-uncapping function. Lack of functional RLTPR/CARMIL2 impedes differentiation toward Th1 and Th17 fates in CD4+ T cells, leading to combined immunodeficiency. Expression is also detected in human and murine B cells but appears unrelated to BCR-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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