Thermo Fisher Scientific TRPM4 Monoclonal Antibody (OTI3C4), TrueMAB
인간 TRPM4 단백질을 표적으로 하는 단일클론 항체로, Western blot에 최적화됨. Mouse IgG1 형식의 TrueMAB 제품으로 높은 특이성과 재현성을 제공. 액상 형태로 안정적인 보관 및 운송 가능. 연구용으로만 사용.
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Thermo Fisher Scientific TRPM4 Monoclonal Antibody (OTI3C4), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C4 |
| Immunogen | Full-length protein expressed in 293T cell transfected with human TRPM4 expression vector |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization. Activated by increased intracellular Ca²⁺ but impermeable to it. Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization. Plays a central role in cardiomyocytes, neurons (entorhinal cortex, dorsal root, vomeronasal), endocrine pancreas cells, kidney epithelial cells, and cochlea hair cells. Participates in T-cell activation via Ca²⁺ oscillation modulation, required for NFAT-dependent IL2 production. Involved in cerebral artery myogenic constriction and insulin secretion control in pancreatic beta-cells. May contribute to pacemaking and irregular electrical activity under Ca²⁺ overload. Regulates Th1/Th2 cell motility and cytokine production via calcium signaling and NFATC1 localization. Enhances cell proliferation through β-catenin signaling pathway up-regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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