Thermo Fisher Scientific USP13 Monoclonal Antibody (OTI5B9), TrueMAB
USP13 단백질을 인식하는 마우스 단클론 항체로 Western blot 및 Immunoprecipitation에 적합. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 완충액에 보존. 인간 시료 반응성, 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunoprecipitation (IP) | 4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B9 |
| Immunogen | Full-length protein expressed in 293T cells transfected with human USP13 expression vector |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.83 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2, and USP10. It participates in processes including autophagy and endoplasmic reticulum-associated degradation (ERAD). USP13 is part of a regulatory loop controlling autophagy and p53/TP53 levels by stabilizing PIK3C3/VPS34-containing complexes and deubiquitinating USP10. It also mediates deubiquitination of SKP2 and UBL4A, regulating ERAD. Additionally, USP13 stabilizes SIAH2 independently of deubiquitinase activity by impairing SIAH2 autoubiquitination. It has weak deubiquitinase activity in vitro and preferentially cleaves Lys-63-linked polyubiquitin chains. It can cleave ISG15 in vitro, though further confirmation is needed. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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