Thermo Fisher Scientific TRPM4 Monoclonal Antibody (OTI14C3), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization. While it is activated by an increase in intracellular Ca²⁺, it is impermeable to it. Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization. Plays a central role in cardiomyocytes, neurons from the entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, and cochlear hair cells. Participates in T-cell activation by modulating Ca²⁺ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries and controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or cause irregular electrical activity under conditions of Ca²⁺ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.