Thermo Fisher Scientific PRMT6 Monoclonal Antibody (4G2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-15584 targets PRMT6 in indirect ELISA and Western blot applications and shows reactivity with human and non-human primate samples.
The immunogen is a purified recombinant fragment of human PRMT6 expressed in E. coli.
MA5-15584 detects PRMT6, which has a predicted molecular weight of approximately 42 kDa.

Target Information

Protein arginine N-methyltransferase 6 (PRMT6) demonstrates type I PRMT activity, capable of forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on recombinant glycine- and arginine-rich substrates.
Acts as a transcriptional coactivator of several steroid hormone receptors, including ESR1, ESR2, PGR, and NR3C1.
Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator.
May play a role in innate immunity against HIV-1 by methylating and impairing the function of viral proteins such as Tat, Rev, and nucleocapsid protein p7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.