Thermo Fisher Scientific HDAC4 Monoclonal Antibody (7B2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-15580 targets HDAC4 in indirect ELISA and Western blot applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human HDAC4 expressed in E. coli.
MA5-15580 detects HDAC4 with a predicted molecular weight of approximately 119 kDa.

Target Information

Histone deacetylase 4 (HDAC4) is responsible for deacetylating lysine residues on the N-terminal part of core histones (H2A, H2B, H3, and H4).
This deacetylation serves as an epigenetic repression marker and plays a key role in transcriptional regulation, cell cycle progression, and developmental processes.
HDAC4 acts through large multiprotein complexes and is involved in muscle maturation via interactions with myocyte enhancer factors (MEF2A, MEF2C, MEF2D).
It also participates in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Mutations in the HDAC4 gene have been associated with Brachydactyly-mental retardation syndrome (BDMR).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.