Thermo Fisher Scientific STAT2 Monoclonal Antibody (STAT2, 2650)
STAT2 단백질을 인식하는 Mouse monoclonal antibody로, IHC(P) 등 다양한 응용에 적합. Human 시료 반응성. 단백질 A/G 정제 및 PBS buffer, 보존제 없음. 연구용으로 STAT 신호전달 연구에 활용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STAT2, 2650 |
| Immunogen | Recombinant full-length human STAT2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, forming homo- or heterodimers that translocate to the nucleus to act as transcription activators.
Upon interferon (IFN) stimulation, STAT2 forms a complex with STAT1 and p48 (ISGF3G), functioning as a transactivator without direct DNA binding. STAT2 interacts with transcription adaptor P300/CBP (EP300/CREBBP) and may be involved in blocking IFN-alpha responses by adenovirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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