Thermo Fisher Scientific STAT2 Monoclonal Antibody (STAT2, 2650)
STAT2 단백질을 표적하는 마우스 모노클로날 항체로, 인간 시료에 반응합니다. IHC(P) 실험에 적합하며, 단백질 A/G로 정제된 액상 형태입니다. STAT2 신호전달 연구 및 사이토카인 반응 분석용 연구 시약입니다.
- 카탈로그번호
- 6773-MSM2-P1
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STAT2, 2650 |
| Immunogen | Recombinant full-length human STAT2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and form homo- or heterodimers that translocate to the nucleus to act as transcription activators.
In response to interferon (IFN), STAT2 forms a complex with STAT1 and IFN regulatory factor p48 (ISGF3G), acting as a transactivator but lacking direct DNA-binding ability. Transcription adaptor P300/CBP (EP300/CREBBP) interacts specifically with STAT2, which may be involved in blocking IFN-alpha response by adenovirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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