Thermo Fisher Scientific BUB1B Monoclonal Antibody (OTI11D7), TrueMAB
BUB1B 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC/IF에 사용 가능. Human 시료에 반응하며, 동결건조 형태로 제공. PBS 버퍼에 8% 트레할로오스 포함, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11D7 |
| Immunogen | Full-length protein expressed in 293T cells transfected with human BUB1B expression vector |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
BUBR1 (BUB1B) is a member of the Ser/Thr protein kinase family and a key component of the mitotic checkpoint, ensuring proper chromosome attachment before anaphase.
Defects in this checkpoint can lead to genetic instability and malignant transformation.
Human cells express two related kinases, hBUBR1 and hBUB1, both monitoring kinetochore-microtubule interactions.
BUBR1 is essential for normal mitotic progression and has been implicated in various human cancers, including breast cancer, where it interacts with BCSG1 to affect checkpoint control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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