Thermo Fisher Scientific GRLF1 Monoclonal Antibody (4D4-F8)

Applications

• ELISA (ELISA)
  Tested Dilution: 0.1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MEATSRSVHG DVGEVGHFEG MAVCWCPRRG ILPGLR

Target Information

RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA, and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo. To maintain rapid growth, cells must produce high levels of Pol III transcribed RNA, requiring TFIIIB and TFIIIC2 transcription factor complexes.
The TFIIIC2 complex consists of five subunits — TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, and TFIIIC63 — which are overexpressed in adenovirus-transformed and malignant cells such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be key in malignant cell deregulation.
The TFIIIB complex includes TATA-binding protein (TBP), TFIIB-related factor 1 (TFIIIB90, BRF1), and TFIIIB, which are also upregulated in transformed cells. In many carcinomas, tumor suppressors RB and p53 are inactivated, affecting their ability to bind and inactivate TFIIIB.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.