Thermo Fisher Scientific ATG3 Polyclonal Antibody

Thermo Fisher Scientific ATG3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution, keep aliquots at -20°C for higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.

Target Information

ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy is a process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, important for normal growth control and may be defective in tumor cells. It helps preserve cellular nutrients under starvation and supports normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA1-18297_ATG3_Q9NT62-1_Rabbit.svg, PA1-18297_ATG3_Q9NT62-1_Rabbit_PDP.jpeg)