Thermo Fisher Scientific SIRT1 Monoclonal Antibody (OTI1H1), TrueMAB

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation to intracellular energetics and coordinates various cellular processes such as cell cycle control, DNA damage response, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through histone deacetylation and influences histone and DNA methylation, leading to transcriptional repression. It plays a critical role in skeletal muscle differentiation and nutrient response, involving AMPK and NAMPT pathways.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.