Thermo Fisher Scientific SIRT1 Monoclonal Antibody (OTI1H1), TrueMAB
SIRT1 단백질을 인식하는 단클론 항체로, Western blot에 최적화됨. 인간, 생쥐, 랫드 반응성. 동결건조 형태로 제공되며, PBS buffer와 trehalose 포함. 연구용으로 세포 대사 및 DNA 손상 반응 연구에 활용 가능.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 552–676 of human SIRT1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation to intracellular energetics and coordinates various cellular processes such as cell cycle control, DNA damage response, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through histone deacetylation and influences histone and DNA methylation, leading to transcriptional repression. It plays a critical role in skeletal muscle differentiation and nutrient response, involving AMPK and NAMPT pathways.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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