Thermo Fisher Scientific PCNA (Proliferating Cell Nuclear Antigen) (G1- and S-phase Marker) Recombinant Mouse Monoclonal Antibody (rPCNA/8859)
PCNA 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 마우스 단클론 항체입니다. 인간 시료에 반응하며 G1- 및 S-기 세포주기 표지자로 사용됩니다. IHC(P) 등 다양한 응용에 적합하며, 높은 순도와 안정적인 액상 형태로 제공됩니다.
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- 5111-MSM12-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PCNA (Proliferating Cell Nuclear Antigen) (G1- and S-phase Marker) Recombinant Mouse Monoclonal Antibody (rPCNA/8859)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rPCNA/8859 |
| Immunogen | Recombinant full-length human PCNA protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: HEK293 or U937 cells, tonsil or reactive lymph node, SKBr3
- Cellular Location: Nucleus, Cytoplasm
Target Information
PCNA (Proliferating Cell Nuclear Antigen) is essential for DNA replication and plays a key role in DNA excision and mismatch repair pathways.
It binds to CDK inhibitor p21, endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT).
PCNA serves as a marker for proliferating cells and is used to assess tumor proliferation status and prognosis.
It is expressed in the nucleus, functions as a cofactor of DNA polymerase delta, and forms a homotrimer to enhance leading strand synthesis during replication.
Upon DNA damage, PCNA is ubiquitinated and participates in the RAD6-dependent DNA repair pathway.
Two transcript variants encoding the same protein are known, and pseudogenes are described on chromosome 4 and the X chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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