Thermo Fisher Scientific EDG6 Polyclonal Antibody
Rabbit polyclonal antibody against human EDG6 (S1P4). Validated for IHC-P with high specificity. Recognizes conserved regions across species. Suitable for research on G-protein coupled receptor signaling and sphingosine-1-phosphate pathways. For resear...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 9.6 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from 2nd cytoplasmic domain of human S1PR4 / EDG6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551536 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla (100%); Monkey, Marmoset, Mouse, Rat, Hamster (95%); Bovine, Pig (85%); Panda, Dog (80%).
Target Information
EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family, which mediate growth-related effects such as induction of cellular proliferation, differentiation, survival, and suppression of apoptosis. They also regulate cellular effector functions including contraction, secretion, adhesion, and chemotaxis.
EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through Ras, MAP kinase, Rho, phospholipase C, and several protein tyrosine kinases.
EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissues and in the lungs. The updated designation for EDG6 (S1P4) is sphingosine 1-phosphate receptor-4 (S1P4).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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