Thermo Fisher Scientific EDG6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla (100%); Monkey, Marmoset, Mouse, Rat, Hamster (95%); Bovine, Pig (85%); Panda, Dog (80%).

Target Information

EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family, which mediate growth-related effects such as induction of cellular proliferation, differentiation, survival, and suppression of apoptosis. They also regulate cellular effector functions including contraction, secretion, adhesion, and chemotaxis.
EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through Ras, MAP kinase, Rho, phospholipase C, and several protein tyrosine kinases.
EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissues and in the lungs. The updated designation for EDG6 (S1P4) is sphingosine 1-phosphate receptor-4 (S1P4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.