Thermo Fisher Scientific S1P1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human S1P1 receptor. Validated for IHC (Paraffin) at 6 µg/mL. Antigen affinity purified and supplied as a liquid in PBS with 0.1% sodium azide. Store at 4°C short term or -20°C long term. For research use only.
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- PA534180
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from C-terminus of human S1PR1 / EDG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551533 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Orangutan, Gibbon, Monkey, Panda (100%)
Marmoset, Bovine, Cat, Pig (95%)
Target Information
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins.
S1P1 signaling leads to activation of RAC1, SRC, PTK2/FAK1, and MAP kinases.
It plays an important role in cell migration via actin cytoskeleton reorganization and lamellipodia formation in response to sphingosine kinase SPHK1 activity.
S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and cardiac morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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